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Recent advances in myeloid-derived suppressor cell biology
Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Homa Darmani, Ammar Daoud
《医学前沿(英文)》 2021年 第15卷 第2期 页码 232-251 doi: 10.1007/s11684-020-0797-2
关键词: non-human primates (rhesus macaques) myeloid-derived pro-inflammatory cells (MDPCs) autoimmune disorders alloimmune responses pregnancy mature MDSCs multiple sclerosis Yin-Yang law of MDSCs
Dongping Ning, Zhan Zhang, Kun Qiu, Lin Lu, Qin Zhang, Yan Zhu, Renzhi Wang
《医学前沿(英文)》 2020年 第14卷 第4期 页码 498-505 doi: 10.1007/s11684-020-0791-8
关键词: disorders of sex development (DSD) intelligent diagnosis dynamic uncertain causality graph
The critical importance of epigenetics in autoimmune-related skin diseases
《医学前沿(英文)》 2023年 第17卷 第1期 页码 43-57 doi: 10.1007/s11684-022-0980-8
关键词: epigenetics autoimmune-related skin diseases DNA methylation histone modifications noncoding RNAs
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《医学前沿(英文)》 2015年 第9卷 第2期 页码 187-219 doi: 10.1007/s11684-015-0386-y
Autoimmune hepatitis is a chronic liver disease putatively caused by loss of tolerance to hepatocyte-specific autoantigens. It is characterized by female predilection, elevated aminotransferase levels, autoantibodies, increased γ-globulin or IgG levels and biopsy evidence of interface hepatitis. It is currently divided into types 1 and 2, based on expression of autoantibodies. Autoantigenic epitopes have been identified only for the less frequent type 2. Although autoimmune hepatitis occurs in childhood, this review focuses on disease in adults. In the absence of pathognomonic biomarkers, diagnosis requires consideration of clinical, biochemical, serological and histological features, which have been codified into validated diagnostic scoring systems. Since many features also occur in other chronic liver diseases, these scoring systems aid evaluation of the differential diagnosis. New practice guidelines have redefined criteria for remission to include complete biochemical and histological normalization on immunosuppressive therapy. Immunosuppression is most often successful using prednisone or prednisolone and azathioprine; however, the combination of budesonide and azathioprine for non-cirrhotic patients offers distinct advantages. Patients failing standard immunosuppression are candidates for alternative immunosuppressive regimens, yet none of the options has been studied in a randomized, controlled trial. Overlap syndromes with either primary sclerosing cholangitis or primary biliary cirrhosis occur in a minority. Liver transplantation represents a life-saving option for patients presenting with acute liver failure, severely decompensated cirrhosis or hepatocellular carcinoma. Transplant recipients are at risk for recurrent autoimmune hepatitis in the allograft, and de novo disease may occur in patients transplanted for other indications. Patients transplanted for AIH are also at risk for recurrent or de novo inflammatory bowel disease. Progress in our understanding of the immunopathogenesis should lead to identification of specific diagnostic and prognostic biomarkers and new therapeutic strategies.
关键词: autoimmune hepatitis autoantibodies diagnosis immunological diseases drug-induced liver injury therapy immunosuppression outcomes hepatocellular carcinoma liver transplantation
《医学前沿(英文)》 2023年 第17卷 第3期 页码 534-548 doi: 10.1007/s11684-022-0953-y
关键词: autoimmune hepatitis (AIH) concanavalin A (Con A) human menstrual blood-derived stem cells (MenSCs) apoptosis mitogen-activated protein kinase (MAPK)
Th17 Cells in autoimmune diseases
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《医学前沿(英文)》 2015年 第9卷 第1期 页码 10-19 doi: 10.1007/s11684-015-0388-9
Th17 cells are a new subset of CD4+ T cells involved in the clearance of extracellular pathogens and fungi. Accumulating evidence suggests that Th17 cells and their signature cytokines have a pivotal role in the pathogenesis of multiple autoimmune-mediated inflammatory diseases. Here, we summarize recent research progress on Th17 function in the development and pathogenesis of autoimmune diseases. We also propose to identify new small molecule compounds to manipulate Th17 function for potential therapeutic application to treat human autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sj?gren’s syndrome, inflammatory bowel disease, and multiple sclerosis.
关键词: IL-17 Th17 cells RORγt autoimmune diseases posttranslational modification inhibitors
Therapeutic effects of thalidomide in hematologic disorders: a review
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《医学前沿(英文)》 2013年 第7卷 第3期 页码 290-300 doi: 10.1007/s11684-013-0277-z
The extensive autoimmune, anti-inflammatory, and anticancer applications of thalidomide have inspired a growing number of studies and clinical trials. As an inexpensive agent with relatively low toxicity, thalidomide is regarded as a promising therapeutic candidate, especially for malignant diseases. We review its therapeutic effects in hematology, including those on multiple myeloma, Waldenstroem macroglobulinemia, lymphoma, mantle-cell lymphoma, myelodysplastic syndrome, hereditary hemorrhagic telangiectasia, and graft-versus-host disease. Most studies have shown satisfactory results, although several have reported the opposite. Aside from optimal outcomes, the toxicities and adverse effects of thalidomide should also be examined. The current work includes a discussion of the mechanisms through which the novel biological effects of thalidomide occur, although more studies should be devoted to this aspect. With appropriate safeguards, thalidomide may benefit patients suffering from a broad variety of disorders, particularly refractory and resistant diseases.
Diagnostic criteria of latent autoimmune diabetes in adults (LADA): a review and reflection
Yu Liao, Yufei Xiang, Zhiguang Zhou
《医学前沿(英文)》 2012年 第6卷 第3期 页码 243-247 doi: 10.1007/s11684-012-0201-y
关键词: LADA diagnostic criteria autoantibodies insulin independence age of diagnosis
Mesenchymal stem cells and immune disorders: from basic science to clinical transition
Shihua Wang, Rongjia Zhu, Hongling Li, Jing Li, Qin Han, Robert Chunhua Zhao
《医学前沿(英文)》 2019年 第13卷 第2期 页码 138-151 doi: 10.1007/s11684-018-0627-y
关键词: mesenchymal stem cell clinical transition immune disorders
《医学前沿(英文)》 doi: 10.1007/s11684-023-1006-x
关键词: neurodevelopmental disorder autosomal recessive intellectual disability consanguinity spastic paraplegia hearing loss TMEM141
Autoimmune regulator regulates autophagy in THP-1 human monocytes
Liang SHI, Li-Hua HU, Yi-Rong LI
《医学前沿(英文)》 2010年 第4卷 第3期 页码 336-341 doi: 10.1007/s11684-010-0096-4
关键词: autoimmune regulator autophagy monocytes light chain 3 (LC3)
Yuqiu Han, Xiangyang Jiang, Qi Ling, Li Wu, Pin Wu, Ruiqi Tang, Xiaowei Xu, Meifang Yang, Lijiang Zhang, Weiwei Zhu, Baohong Wang, Lanjuan Li
《医学前沿(英文)》 2019年 第13卷 第4期 页码 471-481 doi: 10.1007/s11684-019-0686-8
XU Leping, JI Juying, DUAN Yiyang, SHI Hui, ZHANG Bin, SHAO Yaqin, SUN Jian
《医学前沿(英文)》 2007年 第1卷 第3期 页码 316-319 doi: 10.1007/s11684-007-0061-z
关键词: significant difference occurrence hemoglobin risperidone treatment abnormal
人工智能算法在精神疾病中的应用简述 Review
刘光迪, 李雨辰, 张伟, 章乐
《工程(英文)》 2020年 第6卷 第4期 页码 462-467 doi: 10.1016/j.eng.2019.06.008
为了研究精神疾病的病因和发病机制,各国开展了大量脑研究计划。尽管精神疾病是脑科学研究的重要部分,但精神疾病的诊断仍然依靠医生的主观经验,而非疾病的病理生理学指标。因此,为了开发有效的治疗方式和干预措施,我们迫切需要对重大精神疾病的病因和致病机制有一个清晰的认识。当前,人工智能(AI)技术在精神疾病的应用研究发展迅速,但缺少对其进行系统化的总结和展望。因此,本研究简要回顾了用于研究精神疾病的三种主要观测技术,即磁共振成像(MRI)、脑电图(EEG)和基于体势学的诊断(与模式识别相关的AI算法)。最后,我们讨论了AI应用面临的挑战、机遇和未来的发展方向。
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《医学前沿(英文)》 2018年 第12卷 第3期 页码 262-268 doi: 10.1007/s11684-017-0584-x
γδ T cells display unique developmental, distributional, and functional patterns and can rapidly respond to various insults and contribute to diverse diseases. Different subtypes of γδ T cells are produced in the thymus prior to their migration to peripheral tissues. γδ T cells are enriched in the liver and exhibit liver-specific features. Accumulating evidence reveals that γδ T cells play important roles in liver infection, non-alcoholic fatty liver disease, autoimmune hepatitis, liver fibrosis and cirrhosis, and liver cancer and regeneration. In this study, we review the properties of hepatic γδ T cells and summarize the roles of γδ T cells in liver diseases. We believe that determining the properties and functions of γδ T cells in liver diseases enhances our understanding of the pathogenesis of liver diseases and is useful for the design of novel γδ T cell-based therapeutic regimens for liver diseases.
关键词: γδT cells liver infection non-alcoholic fatty liver disease autoimmune hepatitis liver fibrosis and cirrhosis liver cancer liver regeneration
标题 作者 时间 类型 操作
Recent advances in myeloid-derived suppressor cell biology
Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Homa Darmani, Ammar Daoud
期刊论文
Efficacy of intelligent diagnosis with a dynamic uncertain causality graph model for rare disorders of
Dongping Ning, Zhan Zhang, Kun Qiu, Lin Lu, Qin Zhang, Yan Zhu, Renzhi Wang
期刊论文
Human menstrual blood-derived stem cells alleviate autoimmune hepatitis via JNK/MAPK signaling pathway
期刊论文
Diagnostic criteria of latent autoimmune diabetes in adults (LADA): a review and reflection
Yu Liao, Yufei Xiang, Zhiguang Zhou
期刊论文
Mesenchymal stem cells and immune disorders: from basic science to clinical transition
Shihua Wang, Rongjia Zhu, Hongling Li, Jing Li, Qin Han, Robert Chunhua Zhao
期刊论文
Panoramic variation analysis of a family with neurodevelopmental disorders caused by biallelic loss-of-function
期刊论文
Autoimmune regulator regulates autophagy in THP-1 human monocytes
Liang SHI, Li-Hua HU, Yi-Rong LI
期刊论文
Antibiotics-mediated intestinal microbiome perturbation aggravates tacrolimus-induced glucose disorders
Yuqiu Han, Xiangyang Jiang, Qi Ling, Li Wu, Pin Wu, Ruiqi Tang, Xiaowei Xu, Meifang Yang, Lijiang Zhang, Weiwei Zhu, Baohong Wang, Lanjuan Li
期刊论文
Abnormal glycosylated hemoglobin as a predictive factor for glucose metabolism disorders in antipsychotic
XU Leping, JI Juying, DUAN Yiyang, SHI Hui, ZHANG Bin, SHAO Yaqin, SUN Jian
期刊论文